Before Methamphetamine addiction treatment, you must know what Methamphetamine is. Methamphetamine (contracted from N-methylamphetamine) is a potent central nervous system stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity
Methamphetamine is contraindicated in individuals with a history of a substance use disorder, heart disease, or severe agitation or anxiety, or in individuals currently experiencing arteriosclerosis, glaucoma, hyperthyroidism, or severe hypertension.
The FDA strongly advises that individuals who have experienced hypersensitivity reactions to other stimulants in the past or are currently taking monoamine oxidase inhibitors should not take methamphetamine.
Methamphetamine produces feelings of euphoria for up to 12 hours, and users crave its powerful effect again and again. A person can become addicted after using methamphetamine only a few times because
after several uses, the same dose does not have the same effect as it first did.
Then tolerance develops, and users need more of the drug to achieve the same effect as before. In time, the aspiration to get “high” becomes more important than other factors in the user’s life, while the use of the drug increasingly achieves only a break from withdrawal symptoms.
Current models of addiction from chronic drug use involve alterations in gene expression in certain parts of the brain, particularly the nucleus accumbens.
The most important transcription factors that produce these alterations are ΔFosB, cAMP response element-binding protein (CREB), and nuclear factor kappa B (NFκB)
These alterations have been implicated in addictions to alcohol, cannabinoids, cocaine, methylphenidate, nicotine, opioids, phencyclidine, propofol, and substituted amphetamines, among others.
Epigenetic factors in methamphetamine addiction
Methamphetamine addiction is persistent for many individuals, with 61% of individuals treated for addiction relapsing within a year. About half of those with methamphetamine addiction continues with use over a ten-year period, while the other half reduce use starting at about one to four years after initial use.
The frequent persistence of addiction suggests that long-lasting changes in gene expression may occur in particular selected parts of the brain, and may contribute importantly to the addiction phenotype. Recently a crucial role has been found for epigenetic mechanisms in drawing lasting changes in gene expression in the brain.
Methamphetamine Addiction Treatment And Rehabilitation
A 2018 systematic review and network meta-analysis of 50 Methamphetamine addiction treatment trials involving 12 different psychosocial interventions, methamphetamine, or cocaine addiction found that combination therapy with contingency management and community reinforcement approach had the highest efficacy (i.e., abstinence rate) and acceptability (i.e., lowest dropout rate).
Other Methamphetamine addiction treatment modalities examined in the analysis included monotherapy with contingency management or community reinforcement approach, cognitive behavioral therapy, 12-step programs, non-contingent reward-based therapies, psychodynamic therapy, and other combination therapies involving these.
As of December 2019, there is no effective pharmacotherapy for Crystal Methamphetamine addiction treatment A systematic review and meta-analysis from 2019 assessed the efficacy of 17 different pharmacotherapies used in RCTs for amphetamine and methamphetamine addiction; it found only low-strength evidence that methylphenidate might reduce amphetamine or methamphetamine self-administration.
Methamphetamine Treatment withdrawal effects
Tolerance is expected to come with regular methamphetamine use and, when used recreationally, this tolerance develops rapidly. withdrawal symptoms are positively correlated with the level of drug tolerance. Depression from methamphetamine withdrawal could last longer and more severe than that of cocaine withdrawal.
These Withdrawal effects include
- severe depression
Methamphetamine Withdrawal Symptoms can last for days or weeks, depending on how long the addiction has lasted.